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Randomized controlled pilot trial of mindfulness-based stress reduction compared to psychoeducational support for persistently fatigued breast and colorectal cancer survivors.


ABSTRACT: PURPOSE:Cancer-related fatigue (CRF) is a disruptive symptom for many survivors. Despite promising evidence for efficacy of mindfulness-based stress reduction (MBSR) in reducing CRF, no trials comparing it to an active comparator for fatigued survivors have been published. The purpose of this trial was to compare MBSR to psychoeducation for CRF and associated symptoms. METHODS:Breast (n = 60) and colorectal (n = 11) cancer survivors (stage 0-III) with clinically significant CRF after completing chemotherapy and/or radiation therapy an average of 28 months prior to enrollment were randomized to MBSR or psychoeducation/support groups (PES). MBSR focused on mindfulness training; PES focused on CRF self-management. Outcomes included CRF interference (primary), CRF severity and global improvement, vitality, depression, anxiety, sleep disturbance, and pain. Outcomes were assessed at baseline (T1), post-intervention (T2), and 6-month follow-up (T3) using intent-to-treat analysis. RESULTS:Between-group differences in CRF interference were not significant at any time point; however, there was a trend favoring MBSR (d = -0.46, p = 0.073) at T2. MBSR participants reported significantly greater improvement in vitality (d = 0.53, p = 0.003) and were more likely to report CRF as moderately to completely improved compared to the PES group (?2 (1) = 4.1765, p = 0.041) at T2. MBSR participants also reported significantly greater reductions in pain at T2 (d = 0.53, p = 0.014). In addition, both MBSR and PES produced moderate-to-large and significant within-group improvements in all fatigue outcomes, depression, anxiety, and sleep at T2 and T3 compared to T1. CONCLUSION:MBSR and PES appear efficacious for CRF and related symptoms. Larger trials including a usual care arm are warranted. TRIAL REGISTRATION:ClinicalTrials.gov Identifier: NCT01724333.

SUBMITTER: Johns SA 

PROVIDER: S-EPMC5221754 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Randomized controlled pilot trial of mindfulness-based stress reduction compared to psychoeducational support for persistently fatigued breast and colorectal cancer survivors.

Johns Shelley A SA   Brown Linda F LF   Beck-Coon Kathleen K   Talib Tasneem L TL   Monahan Patrick O PO   Giesler R Brian RB   Tong Yan Y   Wilhelm Laura L   Carpenter Janet S JS   Von Ah Diane D   Wagner Christina D CD   de Groot Mary M   Schmidt Karen K   Monceski Diane D   Danh Marie M   Alyea Jennifer M JM   Miller Kathy D KD   Kroenke Kurt K  

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20160517 10


<h4>Purpose</h4>Cancer-related fatigue (CRF) is a disruptive symptom for many survivors. Despite promising evidence for efficacy of mindfulness-based stress reduction (MBSR) in reducing CRF, no trials comparing it to an active comparator for fatigued survivors have been published. The purpose of this trial was to compare MBSR to psychoeducation for CRF and associated symptoms.<h4>Methods</h4>Breast (n = 60) and colorectal (n = 11) cancer survivors (stage 0-III) with clinically significant CRF af  ...[more]

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