Repeated mild traumatic brain injury causes focal response in lateral septum and hippocampus.
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ABSTRACT: Aim
To advance our understanding of regional and temporal cellular responses to repeated mild traumatic brain injury (rmTBI), we used a mouse model of rmTBI that incorporated acceleration, deceleration and rotational forces.Materials & methods
A modified weight-drop method was used to compare two inter-injury intervals, rmTBI-short (five hits delivered over 3 days) and rmTBI-long (five hits delivered over 15 days). Regional investigations of forebrain and midbrain histological alterations were performed at three post-injury time points (immediate, 2 weeks and 6 weeks).Results
The rmTBI-short protocol generated an immediate, localized microglial and astroglial response in the dorsolateral septum and hippocampus, with the astroglial response persisting in the dorsolateral septum. The rmTBI-long protocol showed only a transitory astroglial response in the dorsolateral septum.Conclusion
Our results indicate that the lateral septum and hippocampus are particularly vulnerable regions in rmTBI, possibly contributing to memory and emotional impairments associated with repeated concussions.
SUBMITTER: Acabchuk R
PROVIDER: S-EPMC5222510 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Repeated mild traumatic brain injury causes focal response in lateral septum and hippocampus.
Acabchuk Rebecca R Briggs Denise I DI Angoa-Pérez Mariana M Powers Meghan M Wolferz Richard R Soloway Melanie M Stern Mai M Talbot Lillian R LR Kuhn Donald M DM Conover Joanne C JC
Concussion (London, England) 20160525 3
<h4>Aim</h4>To advance our understanding of regional and temporal cellular responses to repeated mild traumatic brain injury (rmTBI), we used a mouse model of rmTBI that incorporated acceleration, deceleration and rotational forces.<h4>Materials & methods</h4>A modified weight-drop method was used to compare two inter-injury intervals, rmTBI-short (five hits delivered over 3 days) and rmTBI-long (five hits delivered over 15 days). Regional investigations of forebrain and midbrain histological al ...[more]
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