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Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior.


ABSTRACT: Animals host multi-species microbial communities (microbiomes) whose properties may result from inter-species interactions; however, current understanding of host-microbiome interactions derives mostly from studies in which elucidation of microbe-microbe interactions is difficult. In exploring how Drosophila melanogaster acquires its microbiome, we found that a microbial community influences Drosophila olfactory and egg-laying behaviors differently than individual members. Drosophila prefers a Saccharomyces-Acetobacter co-culture to the same microorganisms grown individually and then mixed, a response mainly due to the conserved olfactory receptor, Or42b. Acetobacter metabolism of Saccharomyces-derived ethanol was necessary, and acetate and its metabolic derivatives were sufficient, for co-culture preference. Preference correlated with three emergent co-culture properties: ethanol catabolism, a distinct volatile profile, and yeast population decline. Egg-laying preference provided a context-dependent fitness benefit to larvae. We describe a molecular mechanism by which a microbial community affects animal behavior. Our results support a model whereby emergent metabolites signal a beneficial multispecies microbiome.

SUBMITTER: Fischer CN 

PROVIDER: S-EPMC5222558 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Metabolite exchange between microbiome members produces compounds that influence <i>Drosophila</i> behavior.

Fischer Caleb N CN   Trautman Eric P EP   Crawford Jason M JM   Stabb Eric V EV   Handelsman Jo J   Broderick Nichole A NA  

eLife 20170109


Animals host multi-species microbial communities (microbiomes) whose properties may result from inter-species interactions; however, current understanding of host-microbiome interactions derives mostly from studies in which elucidation of microbe-microbe interactions is difficult. In exploring how <i>Drosophila melanogaster</i> acquires its microbiome, we found that a microbial community influences <i>Drosophila</i> olfactory and egg-laying behaviors differently than individual members. <i>Droso  ...[more]

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