Ontology highlight
ABSTRACT:
SUBMITTER: Al-Jassar C
PROVIDER: S-EPMC5222566 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Al-Jassar Caezar C Andreeva Antonina A Barnabas Deepak D DD McLaughlin Stephen H SH Johnson Christopher M CM Yu Minmin M van Breugel Mark M
Structure (London, England : 1993) 20161222 1
Cilia are thin cell projections with essential roles in cell motility, fluid movement, sensing, and signaling. They are templated from centrioles that dock against the plasma membrane and subsequently extend their peripheral microtubule array. The molecular mechanisms underpinning cilia assembly are incompletely understood. Cep104 is a key factor involved in cilia formation and length regulation that rides on the ends of elongating and shrinking cilia. It is mutated in Joubert syndrome, a geneti ...[more]