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Fibromodulin Is Essential for Fetal-Type Scarless Cutaneous Wound Healing.


ABSTRACT: In contrast to adult and late-gestation fetal skin wounds, which heal with scar, early-gestation fetal skin wounds display a remarkable capacity to heal scarlessly. Although the underlying mechanism of this transition from fetal-type scarless healing to adult-type healing with scar has been actively investigated for decades, in utero restoration of scarless healing in late-gestation fetal wounds has not been reported. In this study, using loss- and gain-of-function rodent fetal wound models, we identified that fibromodulin (Fm) is essential for fetal-type scarless wound healing. In particular, we found that loss of Fm can eliminate the ability of early-gestation fetal rodents to heal without scar. Meanwhile, administration of fibromodulin protein (FM) alone was capable of restoring scarless healing in late-gestation rat fetal wounds, which naturally heal with scar, as characterized by dermal appendage restoration and organized collagen architectures that were virtually indistinguishable from those in age-matched unwounded skin. High Fm levels correlated with decreased transforming growth factor (TGF)-?1 expression and scarless repair, while low Fm levels correlated with increased TGF-?1 expression and scar formation. This study represents the first successful in utero attempt to induce scarless repair in late-gestation fetal wounds by using a single protein, Fm, and highlights the crucial role that the FM-TGF-?1 nexus plays in fetal-type scarless skin repair.

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC5222972 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Fibromodulin Is Essential for Fetal-Type Scarless Cutaneous Wound Healing.

Zheng Zhong Z   Zhang Xinli X   Dang Catherine C   Beanes Steven S   Chang Grace X GX   Chen Yao Y   Li Chen-Shuang CS   Lee Kevin S KS   Ting Kang K   Soo Chia C  

The American journal of pathology 20160922 11


In contrast to adult and late-gestation fetal skin wounds, which heal with scar, early-gestation fetal skin wounds display a remarkable capacity to heal scarlessly. Although the underlying mechanism of this transition from fetal-type scarless healing to adult-type healing with scar has been actively investigated for decades, in utero restoration of scarless healing in late-gestation fetal wounds has not been reported. In this study, using loss- and gain-of-function rodent fetal wound models, we  ...[more]

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