Ontology highlight
ABSTRACT:
SUBMITTER: Nazari B
PROVIDER: S-EPMC5222985 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Nazari Banafsheh B Rice Lisa M LM Stifano Giuseppina G Barron Alexander M S AM Wang Yu Mei YM Korndorf Tess T Lee Jungeun J Bhawan Jag J Lafyatis Robert R Browning Jeffrey L JL
The American journal of pathology 20160823 10
Tissue injury triggers the activation and differentiation of multiple cell types to minimize damage and initiate repair processes. In systemic sclerosis, these repair processes appear to run unchecked, leading to aberrant remodeling and fibrosis of the skin and multiple internal organs, yet the fundamental pathological defect remains unknown. We describe herein a transition wherein the abundant CD34(+) dermal fibroblasts present in healthy human skin disappear in the skin of systemic sclerosis p ...[more]