Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC5223088 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Liu Yi Y Wang Zhantong Z Zhang Huimin H Lang Lixin L Ma Ying Y He Qianjun Q Lu Nan N Huang Peng P Liu Yijing Y Song Jibin J Liu Zhibo Z Gao Shi S Ma Qingjie Q Kiesewetter Dale O DO Chen Xiaoyuan X
Nanoscale 20160501 20
A new type of photothermally responsive nanoprobe based on Edman degradation has been synthesized and characterized. Under irradiation by an 808 nm laser, the heat generated by the gold nanorod core breaks the thiocarbamide structure and releases the fluorescent dye Cy5.5 with increased near-infrared (NIR) fluorescence under mild acidic conditions. This RGD modified nanoprobe is capable of fluorescence imaging of ανβ3 over-expressing U87MG cells in vitro and in vivo. This Edman degradation-based ...[more]