Ontology highlight
ABSTRACT:
SUBMITTER: Nair VS
PROVIDER: S-EPMC5223106 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Nair Varun Sasidharan VS Song Mi Hye MH Ko Myunggon M Oh Kwon Ik KI
Molecules and cells 20161213 12
Stable expression of Foxp3 is ensured by demethylation of CpG motifs in the <i>Foxp3</i> intronic element, the conserved non-coding sequence 2 (CNS2), which persists throughout the lifespan of regulatory T cells (Tregs). However, little is known about the mechanisms on how CNS2 demethylation is sustained. In this study, we found that Ten-Eleven-Translocation (Tet) DNA dioxygenase protects the CpG motifs of CNS2 from re-methylation by DNA methyltransferases (Dnmts) and prevents Tregs from losing ...[more]