Variability in a Short Tandem Repeat Mediates Complex Epistatic Interactions in Arabidopsis thaliana.

ABSTRACT: Short tandem repeats (STRs) are hypervariable genetic elements that occur frequently in coding regions. Their high mutation rate readily generates genetic variation, contributing to adaptive evolution and human diseases. We previously reported that natural ELF3 polyglutamine variants cause reciprocal genetic incompatibilities in two divergent Arabidopsis thaliana backgrounds. Here, we dissect the genetic architecture of this incompatibility, revealing as many as four loci putatively interacting with ELF3 We were able to specifically identify one such ELF3-interacting gene, LSH9 We further used a yeast two-hybrid strategy to identify proteins whose physical interactions with ELF3 were affected by polyglutamine tract length. We found two proteins for which this was the case, ELF4 and AtGLDP1

SUBMITTER: Press MO 

PROVIDER: S-EPMC5223521 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature