Ontology highlight
ABSTRACT:
SUBMITTER: Bulfer SL
PROVIDER: S-EPMC5224236 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Bulfer Stacie L SL Chou Tsui-Fen TF Arkin Michelle R MR
ACS chemical biology 20160613 8
The AAA+ ATPase p97/VCP adopts at least three conformations that depend on the binding of ADP and ATP and alter the orientation of the N-terminal protein-protein interaction (PPI) domain into "up" and "down" conformations. Point mutations that cause multisystem proteinopathy 1 (MSP1) are found at the interface of the N domain and D1-ATPase domain and potentially alter the conformational preferences of p97. Additionally, binding of "adaptor" proteins to the N-domain regulates p97's catalytic acti ...[more]