Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.
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ABSTRACT:
SUBMITTER: Hayakawa Y
PROVIDER: S-EPMC5225031 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.
Hayakawa Yoku Y Sakitani Kosuke K Konishi Mitsuru M Asfaha Samuel S Niikura Ryota R Tomita Hiroyuki H Renz Bernhard W BW Tailor Yagnesh Y Macchini Marina M Middelhoff Moritz M Jiang Zhengyu Z Tanaka Takayuki T Dubeykovskaya Zinaida A ZA Kim Woosook W Chen Xiaowei X Urbanska Aleksandra M AM Nagar Karan K Westphalen Christoph B CB Quante Michael M Lin Chyuan-Sheng CS Gershon Michael D MD Hara Akira A Zhao Chun-Mei CM Chen Duan D Worthley Daniel L DL Koike Kazuhiko K Wang Timothy C TC
Cancer cell 20161215 1
Within the gastrointestinal stem cell niche, nerves help to regulate both normal and neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer-nerve partnership. We find that Dclk1<sup>+</sup> tuft cells and nerves are the main sources of acetylcholine (ACh) within the gastric mucosa. Cholinergic stimulation of the gastric epithelium induced nerve growth factor (NGF) expression, and in turn NGF overexpression within gastric epithelium expanded enteric nerves and promote ...[more]
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