Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5225136 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Zhang Yuwen Y Rao Enyu E Zeng Jun J Hao Jiaqing J Sun Yanwen Y Liu Shujun S Sauter Edward R ER Bernlohr David A DA Cleary Margot P MP Suttles Jill J Li Bing B
Journal of immunology (Baltimore, Md. : 1950) 20161205 2
Macrophages play a critical role in obesity-associated chronic inflammation and disorders. However, the molecular mechanisms underlying the response of macrophages to elevated fatty acids (FAs) and their contribution to metabolic inflammation in obesity remain to be fully elucidated. In this article, we report a new mechanism by which dietary FAs, in particular, saturated FAs (sFAs), are able to directly trigger macrophage cell death. We demonstrated that excess sFAs, but not unsaturated FAs, in ...[more]