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The synthesis of 15N(7)-Hoogsteen face-labeled adenosine phosphoramidite for solid-phase RNA synthesis.
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ABSTRACT: Abstract
We have developed an efficient route for the synthesis of 15N(7)-labeled adenosine as phosphoramidite building block for site- and atom-specific incorporation into RNA by automated solid-phase synthesis. Such labeled RNA is required for the evaluation of selected non-canonical base pair interactions in folded RNA using NMR spectroscopic methods.Graphical abstract
SUBMITTER: Neuner S
PROVIDER: S-EPMC5225212 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
The synthesis of <sup>15</sup>N(7)-Hoogsteen face-labeled adenosine phosphoramidite for solid-phase RNA synthesis.
Monatshefte fur chemie 20161208 1
<h4>Abstract</h4>We have developed an efficient route for the synthesis of <sup>15</sup>N(7)-labeled adenosine as phosphoramidite building block for site- and atom-specific incorporation into RNA by automated solid-phase synthesis. Such labeled RNA is required for the evaluation of selected non-canonical base pair interactions in folded RNA using NMR spectroscopic methods.<h4>Graphical abstract</h4> ...[more]