?? T Cells Coexpressing Gut Homing ?4?7 and ?E Integrins Define a Novel Subset Promoting Intestinal Inflammation.

ABSTRACT: ?? T lymphocytes, dominant T cell subsets in the intestine, mediate both regulatory and pathogenic roles, yet the mechanisms underlying such opposing effects remain unclear. In this study, we identified a unique ?? T cell subset that coexpresses high levels of gut-homing integrins, CD103 and ?4?7. They were exclusively found in the mesenteric lymph node after T cell-mediated colitis induction, and their appearance preceded the inflammation. Adoptive transfer of the CD103+?4?7high subsets enhanced Th1/Th17 T cell generation and accumulation in the intestine, and the disease severity. The level of generation correlated with the disease severity. Moreover, these cells were also found to be elevated in a spontaneous mouse model of ileitis. Based on the procolitogenic function, we referred to this subset as "inflammatory" ?? T cells. Targeting inflammatory ?? T cells may open a novel strategy to treat inflammatory diseases where ?? T cells play a pathogenic role including inflammatory bowel disease.

SUBMITTER: Do JS 

PROVIDER: S-EPMC5225242 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature