Ontology highlight
ABSTRACT:
SUBMITTER: Shukla-Dave A
PROVIDER: S-EPMC5225291 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Shukla-Dave Amita A Castillo-Martin Mireia M Chen Ming M Lobo Jose J Gladoun Nataliya N Collazo-Lorduy Ana A Khan Faisal M FM Ponomarev Vladimir V Yi Zhengzi Z Zhang Weijia W Pandolfi Pier P PP Hricak Hedvig H Cordon-Cardo Carlos C
The American journal of pathology 20161019 12
Increased polyamine synthesis is known to play an important role in prostate cancer. We aimed to explore its functional significance in prostate tumor initiation and its link to androgen receptor (AR) signaling. For this purpose, we generated a new cell line derived from normal epithelial prostate cells (RWPE-1) with overexpression of ornithine decarboxylase (ODC) and used it for in vitro and in vivo experiments. We then comprehensively analyzed the expression of the main metabolic enzymes of th ...[more]