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From an indirect response pharmacodynamic model towards a secondary signal model of dose-response relationship between exercise training and physical performance.

ABSTRACT: The aim of this study was to test the suitability of using indirect responses for modeling the effects of physical training on performance. We formulated four different models assuming that increase in performance results of the transformation of a signal secondary to the primary stimulus which is the training dose. The models were designed to be used with experimental data with daily training amounts ascribed to input and performance measured at several dates ascribed to output. The models were tested using data obtained from six subjects who trained on a cycle ergometer over a 15-week period. The data fit for each subject was good for all of the models. Goodness-of-fit and consistency of parameter estimates favored the model that took into account the inhibition of production of training effect. This model produced an inverted-U shape graphic when plotting daily training dose against performance because of the effect of one training session on the cumulated effects of previous sessions. In conclusion, using secondary signal-dependent response provided a framework helpful for modeling training effect which could enhance the quantitative methods used to analyze how best to dose physical activity for athletic performance or healthy living.

SUBMITTER: Busso T

PROVIDER: S-EPMC5225461 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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From an indirect response pharmacodynamic model towards a secondary signal model of dose-response relationship between exercise training and physical performance.

Busso Thierry T

Scientific reports 20170111

The aim of this study was to test the suitability of using indirect responses for modeling the effects of physical training on performance. We formulated four different models assuming that increase in performance results of the transformation of a signal secondary to the primary stimulus which is the training dose. The models were designed to be used with experimental data with daily training amounts ascribed to input and performance measured at several dates ascribed to output. The models were ...[more]

PMID: 28074875

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Project description:Transit compartments (TC) models are used to describe pharmacodynamic responses that involve drug action on cells undergoing differentiation and maturation. Such pharmacodynamic systems can also be described by lifespan based indirect response (LIDR) models. The purpose of this report is to investigate conditions under which the transit compartments models can be considered a special case of LIDR models. An integral representation of a solution to TC model has been used to determine the lifespan distribution for cell population described by this model. The distribution served as a basis for definition of new LIDRE (lifespan based indirect response with an effect on the lifespan distribution) models. Time courses of responses described by both types of models were simulated for a monoexponential pharmacokinetic function. The limit response was calculated as the number of transit compartments approached infinity. The difference between the limit response and TC responses were evaluated by computer simulations using MATLAB 7.7. TC models are a special case of LIDR models with the lifespan distribution described by the gamma function. If drug affects only the production of cells, then the cell lifespan distribution is time invariant. In this case an increase in the number of compartments results in a basic LIDR model with a point lifespan distribution. When the drug inhibits or stimulates cell aging, the cell lifespan distribution becomes time dependent revealing a new mechanism for drug effect on the gamma probability density function. The TC model with a large number of transit compartments converges to an LIDRE model. The limit LIDR models are approximated by the TC models when the number of compartments is at least 5. A moderate improvement in the approximation is observed if this number exceeds 20. The lifespan distribution for a cell population described by a TC model is described by the gamma probability density function. A drug affects this distribution only if it stimulates or inhibits the rate of cell maturation. If the number of transit compartments increases, then the TC model converges to a new type of LIDR model.

Dataset Information

From an indirect response pharmacodynamic model towards a secondary signal model of dose-response relationship between exercise training and physical performance.

Publications

From an indirect response pharmacodynamic model towards a secondary signal model of dose-response relationship between exercise training and physical performance.

Similar Datasets

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