Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells.
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ABSTRACT:
SUBMITTER: Kitahata Y
PROVIDER: S-EPMC5226476 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells.
Kitahata Yuji Y Kanuma Tomohiro T Hayashi Masayuki M Kobayashi Nobuyoshi N Ozasa Koji K Kusakabe Takato T Temizoz Burcu B Kuroda Etsushi E Yamaue Hiroki H Coban Cevayir C Yamamoto Takuya T Kobiyama Kouji K Aoshi Taiki T Ishii Ken J KJ
Oncotarget 20160801 31
Recent evidence suggest that a β-glucan derived from mushroom Schizophyllan(SPG) complexed with a humanized TLR9 agonistic CpG DNA, K3 (K3-SPG) is a promising vaccine adjuvant that induces robust CD8 T cell responses to co-administered antigen. However, it has not been investigated whether K3-SPG alone can act as an anti-cancer immunotherapeutic agent or not. Here, we demonstrate that intravenous injection of K3-SPG, but not CpG alone, is accumulated in the tumor microenvironment and triggered i ...[more]
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