Ontology highlight
ABSTRACT:
SUBMITTER: Samuel N
PROVIDER: S-EPMC5226533 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Samuel Nardin N Wilson Gavin G Id Said Badr B Pan Anna A Deblois Genevieve G Fischer Nicholas W NW Alexandrova Roumiana R Casallo Guillermo G Paton Tara T Lupien Mathieu M Gariepy Jean J Merico Daniele D Hudson Thomas J TJ Malkin David D
Oncotarget 20160801 31
microRNA-34A is a critical component of the p53 network and expression of miR- 34A is down-regulated by promoter hypermethylation or focal deletions in numerous human cancers. Although miR-34A deregulation may be an important driver in cancer, the endogenous role of this microRNA in cellular homeostasis is not well characterized. To address this knowledge gap, we aimed to determine the transcriptional landscape of the miR-34A-p53 axis in non-transformed cells. Using primary skin-derived fibrobla ...[more]