Sensitization of TRPA1 by Protein Kinase A.
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ABSTRACT:
SUBMITTER: Meents JE
PROVIDER: S-EPMC5226813 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Sensitization of TRPA1 by Protein Kinase A.
Meents Jannis E JE Fischer Michael J M MJ McNaughton Peter A PA
PloS one 20170111 1
The TRPA1 ion channel is expressed in nociceptive (pain-sensitive) somatosensory neurons and is activated by a wide variety of chemical irritants, such as acrolein in smoke or isothiocyanates in mustard. Here, we investigate the enhancement of TRPA1 function caused by inflammatory mediators, which is thought to be important in lung conditions such as asthma and COPD. Protein kinase A is an important kinase acting downstream of inflammatory mediators to cause sensitization of TRPA1. By using site ...[more]
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