Ontology highlight
ABSTRACT:
SUBMITTER: Lu F
PROVIDER: S-EPMC5226859 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Lu Fei F Langenbacher Adam A Chen Jau-Nian JN
Developmental biology 20161208 2
Tbx20 is a T-box transcription factor that plays essential roles in the development and maintenance of the heart. Although it is expressed by cardiac progenitors in all species examined, an involvement of Tbx20 in cardiac progenitor formation in vertebrates has not been previously described. Here we report the identification of a zebrafish tbx20 mutation that results in an inactive, truncated protein lacking any functional domains. The cardiac progenitor population is strongly diminished in this ...[more]