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Analysis of extended haplotype in Korean cattle (Hanwoo) population.


ABSTRACT: Korean cattle (Hanwoo) are categorized into three breeds based on color: brown, brindle, and black. Among these breeds, brown Hanwoo has been subjected to intensive selection to improve meat traits. To identify genetic traces driven by recent selection in brown Hanwoo, we scanned the genomes of brown and brindle Hanwoo using a bovine SNP chip. We identified 17 candidate selection signatures in brown Hanwoo and sequenced four candidate regions from 10 individuals each of brown and brindle Hanwoo. In particular, non-synonymous SNPs in the ADSL gene (K88M, L189H, and R302Q) might have had mutational effects on protein structure as a result of altering the purine pathway during nucleotide breakdown. The ADSL gene was previously reported to affect meat quality and yield in livestock. Meat quality and yield are main breeding goals for brown Hanwoo, and our results support a potential causal influence of non-synonymous SNPs in the ADSL gene. [BMB Reports 2016; 49(9): 514-519].

SUBMITTER: Lim D 

PROVIDER: S-EPMC5227145 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Analysis of extended haplotype in Korean cattle (Hanwoo) population.

Lim Dajeong D   Choi Bong Hwan BH   Cho Yong Min YM   Chai Han Ha HH   Jang Gul Won GW   Gondro Cedric C   Jeoung Yeoung Ho YH   Lee Seung Hwan SH  

BMB reports 20160901 9


Korean cattle (Hanwoo) are categorized into three breeds based on color: brown, brindle, and black. Among these breeds, brown Hanwoo has been subjected to intensive selection to improve meat traits. To identify genetic traces driven by recent selection in brown Hanwoo, we scanned the genomes of brown and brindle Hanwoo using a bovine SNP chip. We identified 17 candidate selection signatures in brown Hanwoo and sequenced four candidate regions from 10 individuals each of brown and brindle Hanwoo.  ...[more]

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