Ontology highlight
ABSTRACT:
SUBMITTER: Wei Y
PROVIDER: S-EPMC5228053 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Wei Yao Y Wang Dong D Jin Fangfang F Bian Zhen Z Li Limin L Liang Hongwei H Li Mingzhen M Shi Lei L Pan Chaoyun C Zhu Dihan D Chen Xi X Hu Gang G Liu Yuan Y Zhang Chen-Yu CY Zen Ke K
Nature communications 20170109
Tumour cells secrete exosomes that are involved in the remodelling of the tumour-stromal environment and promoting malignancy. The mechanisms governing tumour exosome release, however, remain incompletely understood. Here we show that tumour cell exosomes secretion is controlled by pyruvate kinase type M2 (PKM2), which is upregulated and phosphorylated in tumours. During exosome secretion, phosphorylated PKM2 serves as a protein kinase to phosphorylate synaptosome-associated protein 23 (SNAP-23) ...[more]