Ontology highlight
ABSTRACT:
SUBMITTER: Caglayan M
PROVIDER: S-EPMC5228075 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Çağlayan Melike M Horton Julie K JK Dai Da-Peng DP Stefanick Donna F DF Wilson Samuel H SH
Nature communications 20170109
Oxidative stress in cells can lead to accumulation of reactive oxygen species and oxidation of DNA precursors. Oxidized purine nucleotides can be inserted into DNA during replication and repair. The main pathway for correcting oxidized bases in DNA is base excision repair (BER), and in vertebrates DNA polymerase β (pol β) provides gap filling and tailoring functions. Here we report that the DNA ligation step of BER is compromised after pol β insertion of oxidized purine nucleotides into the BER ...[more]