Ontology highlight
ABSTRACT:
SUBMITTER: Reeve SM
PROVIDER: S-EPMC5228619 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Reeve Stephanie M SM Scocchera Eric W EW G-Dayanadan Narendran N Keshipeddy Santosh S Krucinska Jolanta J Hajian Behnoush B Ferreira Jacob J Nailor Michael M Aeschlimann Jeffrey J Wright Dennis L DL Anderson Amy C AC
Cell chemical biology 20161208 12
Antibiotic resistance is a rapidly evolving health concern that requires a sustained effort to understand mechanisms of resistance and to develop new agents that overcome those mechanisms. The dihydrofolate reductase (DHFR) inhibitor, trimethoprim (TMP), remains one of the most important orally administered antibiotics. However, resistance through chromosomal mutations and mobile, plasmid-encoded insensitive DHFRs threatens the continued use of this agent. We are pursuing the development of new ...[more]