Mechanochemical functionalization of disulfide linked hydrogels.
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ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC5228622 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Mechanochemical functionalization of disulfide linked hydrogels.
Lee Junmin J Silberstein Meredith N MN Abdeen Amr A AA Kim Sang Yup SY Kilian Kristopher A KA
Materials horizons 20160602 5
Poly(ethylene glycol) hydrogels with disulfide linkages are functionalized through applied force. Compression or tension induces bond rupture at the relatively weak disulfide linkages, which will subsequently react through Michael-type addition with an acceptor molecule within the gel. We demonstrate the utility of this approach by patterning cell adhesion proteins through compression of a lithographically structured stamp, where cells predominately adhere to the compressed regions. ...[more]
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