Ontology highlight
ABSTRACT:
SUBMITTER: Bujak AL
PROVIDER: S-EPMC5233441 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Bujak Adam L AL Crane Justin D JD Lally James S JS Ford Rebecca J RJ Kang Sally J SJ Rebalka Irena A IA Green Alex E AE Kemp Bruce E BE Hawke Thomas J TJ Schertzer Jonathan D JD Steinberg Gregory R GR
Cell metabolism 20150601 6
The AMP-activated protein kinase (AMPK) activates autophagy, but its role in aging and fasting-induced muscle function has not been defined. Here we report that fasting mice lacking skeletal muscle AMPK (AMPK-MKO) results in hypoglycemia and hyperketosis. This is not due to defective fatty acid oxidation, but instead is related to a block in muscle proteolysis that leads to reduced circulating levels of alanine, an essential amino acid required for gluconeogenesis. Markers of muscle autophagy in ...[more]