Ontology highlight
ABSTRACT:
SUBMITTER: Silveira TN
PROVIDER: S-EPMC5233573 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Silveira Tatiana N TN Gomes Marco Túlio R MT Oliveira Luciana S LS Campos Priscila C PC Machado Gabriela G GG Oliveira Sergio C SC
European journal of immunology 20161205 1
Brucella abortus is the causative agent of brucellosis, which causes abortion in domestic animals and undulant fever in humans. This bacterium infects and proliferates mainly in macrophages and dendritic cells, where it is recognized by pattern recognition receptors (PRRs) including Nod-like receptors (NLRs). Our group recently demonstrated the role of AIM2 and NLRP3 in Brucella recognition. Here, we investigated the participation of NLRP12 in innate immune response to B. abortus. We show that N ...[more]