Ontology highlight
ABSTRACT:
SUBMITTER: Hayashi M
PROVIDER: S-EPMC5233800 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Hayashi Masayuki M Aoshi Taiki T Haseda Yasunari Y Kobiyama Kouji K Wijaya Edward E Nakatsu Noriyuki N Igarashi Yoshinobu Y Standley Daron M DM Yamada Hiroshi H Honda-Okubo Yoshikazu Y Hara Hiromitsu H Saito Takashi T Takai Toshiyuki T Coban Cevayir C Petrovsky Nikolai N Ishii Ken J KJ
EBioMedicine 20161201
Advax, a delta inulin-derived microparticle, has been developed as an adjuvant for several vaccines. However, its immunological characteristics and potential mechanism of action are yet to be elucidated. Here, we show that Advax behaves as a type-2 adjuvant when combined with influenza split vaccine, a T helper (Th)2-type antigen, but behaves as a type-1 adjuvant when combined with influenza inactivated whole virion (WV), a Th1-type antigen. In addition, an adjuvant effect was not observed when ...[more]