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Risk of geographic atrophy in age-related macular degeneration patients treated with intravitreal anti-VEGF agents.


ABSTRACT: Anti-vascular endothelial growth factor (VEGF) intravitreal agents are the only successful treatment for wet age-related macular degeneration (AMD). However, there are emerging signals that anti-VEGF treatment can potentially increase development of geographic atrophy (GA). Histopathologic, animal, and clinical studies support this hypothesis although direct proof of a relationship between GA and use of anti-VEGF agents in neovascular AMD is not yet established. This review presents current evidence supporting an association between anti-VEGF therapy and progression of geographic atrophy. The need of exploring alternative methods of treating AMD is indirectly but clearly emphasized.

SUBMITTER: Gemenetzi M 

PROVIDER: S-EPMC5233933 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Risk of geographic atrophy in age-related macular degeneration patients treated with intravitreal anti-VEGF agents.

Gemenetzi M M   Lotery A J AJ   Patel P J PJ  

Eye (London, England) 20161007 1


Anti-vascular endothelial growth factor (VEGF) intravitreal agents are the only successful treatment for wet age-related macular degeneration (AMD). However, there are emerging signals that anti-VEGF treatment can potentially increase development of geographic atrophy (GA). Histopathologic, animal, and clinical studies support this hypothesis although direct proof of a relationship between GA and use of anti-VEGF agents in neovascular AMD is not yet established. This review presents current evid  ...[more]

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