Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt+ Cells in Murine Heart.
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ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5234027 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt<sup>+</sup> Cells in Murine Heart.
Wang Yanwen Y Lin Wee Khang WK Crawford William W Ni Haibo H Bolton Emma L EL Khan Huma H Shanks Julia J Bub Gil G Wang Xin X Paterson David J DJ Zhang Henggui H Galione Antony A Ebert Steven N SN Terrar Derek A DA Lei Ming M
Scientific reports 20170113
In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline. The new murine model enabled the identification of a distinctive class of Pnmt-expressing neuroendocrine cells and their descendants (i.e. Pnmt<sup>+</sup> cell derived cells) within the heart. Here, we show that Pnmt<sup>+</sup> cells predominantly l ...[more]
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