Effectiveness of flexible sigmoidoscopy screening in men and women and different age groups: pooled analysis of randomised trials.

ABSTRACT:

Objective

 To compare the effectiveness of flexible sigmoidoscopy in screening for colorectal cancer by patient sex and age.

Design

 Pooled analysis of randomised trials (the US Prostate, Lung, Colorectal and Ovarian cancer screening trial (PLCO), the Italian Screening for Colon and Rectum trial (SCORE), and the Norwegian Colorectal Cancer Prevention trial (NORCCAP)).

Data sources

 Aggregated data were pooled from each randomised trial on incidence of colorectal cancer and mortality stratified by sex, age at screening, and colon subsite (distal v proximal).

Eligibility criteria for selecting studies

 Invited individuals aged 55-74 (PLCO), 55-64 (SCORE), and 50-64 (NORCCAP). Individuals were randomised to receive flexible sigmoidoscopy screening once only (SCORE

SUBMITTER: Holme O 

PROVIDER: S-EPMC5234564 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature