Dataset Information

Location of Receipt of Initial Treatment and Outcomes in Long-Term Breast Cancer Survivors.

ABSTRACT:

Purpose

Cancer outcomes differ depending on where treatment is received. We assessed differences in outcomes in long-term breast cancer survivors at a specialty care hospital by location of their initial treatment.

Methods

We retrospectively examined a cohort of women diagnosed with invasive early-stage breast cancer who did not experience recurrence for at least 5 years after the date of diagnosis and were evaluated at The University of Texas MD Anderson Cancer Center between January 1997 and August 2008. The location of initial treatment was categorized as MD Anderson (MDA-treated) or other (OTH-treated). Outcomes analyzed included recurrence-free survival (RFS), distant relapse-free survival (DRFS), and overall survival (OS). The Kaplan-Meier product-limit method was used to compare outcomes between the two groups. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI).

Results

We identified 5,091 breast cancer survivors (median follow-up 8.6 years), of whom 89.1% were MDA-treated. The 10-year OS, RFS, and DRFS rates were 90.9%, 88.4%, and 89.0% in the MDA-treated group and 74.3%, 49.8%, and 52.7% in the OTH-treated group, respectively. We observed worse outcomes in the OTH-group in both the univariate analysis and the multivariable analysis (OS: HR = 4.8, 95% CI = 3.9-6.0; RFS: HR = 5.8, 95% CI = 4.8-7.0; DRFS: HR = 5.4, 95% CI = 4.5-6.6).

Conclusion

Long-term breast cancer survivors who initiated their treatment at MD Anderson had better outcomes. Location of initial treatment could be an independent risk factor for survival outcomes at specialty care hospitals. This analysis has limitations inherent to retrospective observational studies such as other unmeasured variables may be associated with worse prognosis.

SUBMITTER: Sinha AK

PROVIDER: S-EPMC5234813 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Location of Receipt of Initial Treatment and Outcomes in Long-Term Breast Cancer Survivors.

Sinha Arup K AK Patel Jenil R JR Shen Yu Y Ueno Naoto T NT Giordano Sharon H SH Tripathy Debu D Lopez David S DS Barcenas Carlos H CH

PloS one 20170113 1

<h4>Purpose</h4>Cancer outcomes differ depending on where treatment is received. We assessed differences in outcomes in long-term breast cancer survivors at a specialty care hospital by location of their initial treatment.<h4>Methods</h4>We retrospectively examined a cohort of women diagnosed with invasive early-stage breast cancer who did not experience recurrence for at least 5 years after the date of diagnosis and were evaluated at The University of Texas MD Anderson Cancer Center between Jan ...[more]

PMID: 28085940

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Dataset Information

Location of Receipt of Initial Treatment and Outcomes in Long-Term Breast Cancer Survivors.

Purpose

Methods

Results

Conclusion

Publications

Location of Receipt of Initial Treatment and Outcomes in Long-Term Breast Cancer Survivors.

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