Ontology highlight
ABSTRACT:
SUBMITTER: Kozlovskaja-Gumbriene A
PROVIDER: S-EPMC5235355 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Kozlovskaja-Gumbrienė Agnė A Yi Ren R Alexander Richard R Aman Andy A Jiskra Ryan R Nagelberg Danielle D Knaut Holger H McClain Melainia M Piotrowski Tatjana T
eLife 20170113
Organ morphogenesis depends on the precise orchestration of cell migration, cell shape changes and cell adhesion. We demonstrate that Notch signaling is an integral part of the Wnt and Fgf signaling feedback loop coordinating cell migration and the self-organization of rosette-shaped sensory organs in the zebrafish lateral line system. We show that Notch signaling acts downstream of Fgf signaling to not only inhibit hair cell differentiation but also to induce and maintain stable epithelial rose ...[more]