Ontology highlight
ABSTRACT:
SUBMITTER: Tran J
PROVIDER: S-EPMC5235972 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
FEBS letters 20161229 1
Aβ42 is the major component of parenchymal plaques in the brain of Alzheimer's patients, while Aβ40 is the major component of cerebrovascular plaques. Since Aβ40 and Aβ42 coexist in the brain, understanding the interaction between Aβ40 and Aβ42 during their aggregation is important to delineate the molecular mechanism underlying Alzheimer's disease. Here, we present a rigorous and systematic study of the cross-seeding effects between Aβ40 and Aβ42. We show that Aβ40 fibril seeds can promote Aβ42 ...[more]