Cross-seeding between A?40 and A?42 in Alzheimer's disease.

ABSTRACT: A?42 is the major component of parenchymal plaques in the brain of Alzheimer's patients, while A?40 is the major component of cerebrovascular plaques. Since A?40 and A?42 coexist in the brain, understanding the interaction between A?40 and A?42 during their aggregation is important to delineate the molecular mechanism underlying Alzheimer's disease. Here, we present a rigorous and systematic study of the cross-seeding effects between A?40 and A?42. We show that A?40 fibril seeds can promote A?42 aggregation in a concentration-dependent manner, and vice versa. Our results also suggest that seeded aggregation and spontaneous aggregation may be two separate pathways. These findings may partly resolve conflicting observations in the literature regarding the cross-seeding effects between A?40 and A?42.

SUBMITTER: Tran J 

PROVIDER: S-EPMC5235972 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature