Ontology highlight
ABSTRACT:
SUBMITTER: Varun D
PROVIDER: S-EPMC5235981 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Varun Divya D Srinivasan Gayathri Rajaram GR Tsai Yi-Huan YH Kim Hyun-Je HJ Cutts Joshua J Petty Francis F Merkley Ryan R Stephanopoulos Nicholas N Dolezalova Dasa D Marsala Martin M Brafman David A DA
Acta biomaterialia 20161027
Despite therapeutic advances, neurodegenerative diseases and disorders remain some of the leading causes of mortality and morbidity in the United States. Therefore, cell-based therapies to replace lost or damaged neurons and supporting cells of the central nervous system (CNS) are of great therapeutic interest. To that end, human pluripotent stem cell (hPSC) derived neural progenitor cells (hNPCs) and their neuronal derivatives could provide the cellular 'raw material' needed for regenerative me ...[more]