Ontology highlight
ABSTRACT:
SUBMITTER: Pruunsild P
PROVIDER: S-EPMC5236011 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Cell reports 20170101 1
Long-term adaptive responses in the brain, such as learning and memory, require synaptic activity-regulated gene expression, which has been thoroughly investigated in rodents. Using human iPSC-derived neuronal networks, we show that the human and the mouse synaptic activity-induced transcriptional programs share many genes and both require Ca<sup>2+</sup>-regulated synapse-to-nucleus signaling. Species-specific differences include the noncoding RNA genes BRE-AS1 and LINC00473 and the protein-cod ...[more]