Ontology highlight
ABSTRACT:
SUBMITTER: Semlow DR
PROVIDER: S-EPMC5237264 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Semlow Daniel R DR Zhang Jieqiong J Budzowska Magda M Drohat Alexander C AC Walter Johannes C JC
Cell 20160929 2
During eukaryotic DNA interstrand cross-link (ICL) repair, cross-links are resolved ("unhooked") by nucleolytic incisions surrounding the lesion. In vertebrates, ICL repair is triggered when replication forks collide with the lesion, leading to FANCI-FANCD2-dependent unhooking and formation of a double-strand break (DSB) intermediate. Using Xenopus egg extracts, we describe here a replication-coupled ICL repair pathway that does not require incisions or FANCI-FANCD2. Instead, the ICL is unhooked ...[more]