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Development of a job-task-exposure matrix to assess occupational exposure to disinfectants among US nurses.


ABSTRACT: Occupational exposure to disinfectants is associated with work-related asthma, especially in healthcare workers. However, little is known about the specific products involved. To evaluate disinfectant exposures, we designed job-exposure (JEM) and job-task-exposure (JTEM) matrices, which are thought to be less prone to differential misclassification bias than self-reported exposure. We then compared the three assessment methods: self-reported exposure, JEM and JTEM.Disinfectant use was assessed by an occupational questionnaire in 9073 US female registered nurses without asthma, aged 49-68?years, drawn from the Nurses' Health Study II. A JEM was created based on self-reported frequency of use (1-3, 4-7?days/week) of 7 disinfectants and sprays in 8 nursing jobs. We then created a JTEM combining jobs and disinfection tasks to further reduce misclassification. Exposure was evaluated in 3 classes (low, medium, high) using product-specific cut-offs (eg, <30%, 30-49.9%, ?50%, respectively, for alcohol); the cut-offs were defined from the distribution of self-reported exposure per job/task.The most frequently reported disinfectants were alcohol (weekly use: 39%), bleach (22%) and sprays (20%). More nurses were classified as highly exposed by JTEM (alcohol 41%, sprays 41%, bleach 34%) than by JEM (21%, 30%, 26%, respectively). Agreement between JEM and JTEM was fair-to-moderate (? 0.3-0.5) for most disinfectants. JEM and JTEM exposure estimates were heterogeneous in most nursing jobs, except in emergency room and education/administration.The JTEM may provide more accurate estimates than the JEM, especially for nursing jobs with heterogeneous tasks. Use of the JTEM is likely to reduce exposure misclassification.

SUBMITTER: Quinot C 

PROVIDER: S-EPMC5237395 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Development of a job-task-exposure matrix to assess occupational exposure to disinfectants among US nurses.

Quinot C C   Dumas O O   Henneberger P K PK   Varraso R R   Wiley A S AS   Speizer F E FE   Goldberg M M   Zock J P JP   Camargo C A CA   Le Moual N N  

Occupational and environmental medicine 20160826 2


<h4>Objectives</h4>Occupational exposure to disinfectants is associated with work-related asthma, especially in healthcare workers. However, little is known about the specific products involved. To evaluate disinfectant exposures, we designed job-exposure (JEM) and job-task-exposure (JTEM) matrices, which are thought to be less prone to differential misclassification bias than self-reported exposure. We then compared the three assessment methods: self-reported exposure, JEM and JTEM.<h4>Methods<  ...[more]

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