PICI: A web server with a multi-parametric algorithm for identifying interaction sites within protein complexes.

ABSTRACT: Identifying interactions between proteins in a complex is essential to analyze their role in various cellular activities and structural stability. Therefore, effective algorithms and computer programs are required for the better understanding of various interactions exist at the protein-protein interface. The protein inter-chain interaction (PICI) server was developed to identify these interaction sites and various interactions that contribute to the specificity and strength of the protein complex by using Protein Interaction Identification Algorithm (PIIA). The multi-parametric approach of this algorithm involves the interface area between the subunits, the atomic coordinate distance, the linearity of bonds, the orientation of aromatic side-chains, and physicochemical properties of the re

SUBMITTER: Das AA 

PROVIDER: S-EPMC5237652 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature