Ontology highlight
ABSTRACT:
SUBMITTER: Marie Kirwen E
PROVIDER: S-EPMC5237703 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Marie Kirwen Erin E Batra Tarun T Karthikeyan Chandrabose C Deora Girdhar Singh GS Rathore Vandana V Mulakayala Chaitanya C Mulakayala Naveen N Nusbaum Amy Catherine AC Chen Joel J Amawi Haneen H McIntosh Kyle K Sahabjada Shivnath Neelam N Chowarsia Deepak D Sharma Nisha N Sharma Nisha N Arshad Md M Trivedi Piyush P Tiwari Amit K AK Tiwari Amit K AK
Acta pharmaceutica Sinica. B 20160806 1
In this study we examined the suitability of the <i>3H</i>-imidazo[4,5-<i>b</i>]pyridine ring system in developing novel anticancer and anti-inflammatory agents incorporating a diaryl pharmacophore. Eight 2,3-diaryl-3<i>H</i>-imidazo[4,5-<i>b</i>]pyridine derivatives retrieved from our in-house database were evaluated for their cytotoxic activity against nine cancer cell lines. The results indicated that the compounds showed moderate cytotoxic activity against MCF-7, MDA-MB-468, K562 and SaOS2 c ...[more]