ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content.
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ABSTRACT:
SUBMITTER: Nowyhed HN
PROVIDER: S-EPMC5238393 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content.
Nowyhed Heba N HN Chandra Shilpi S Kiosses William W Marcovecchio Paola P Andary Farah F Zhao Meng M Fitzgerald Michael L ML Kronenberg Mitchell M Hedrick Catherine C CC
Scientific reports 20170116
ABCA7 is an ABC transporter expressed on the plasma membrane, and actively exports phospholipid complexes from the cytoplasmic to the exocytoplasmic leaflet of membranes. Invariant NKT (iNKT) cells are a subpopulation of T lymphocytes that recognize glycolipid antigens in the context of CD1d-mediated antigen presentation. In this study, we demonstrate that ABCA7 regulates the development of NKT cells in a cell-extrinsic manner. We found that in Abca7<sup>-/-</sup> mice there is reduced expressio ...[more]
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