Ontology highlight
ABSTRACT:
SUBMITTER: Chalhoub H
PROVIDER: S-EPMC5238406 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Chalhoub Hussein H Pletzer Daniel D Weingart Helge H Braun Yvonne Y Tunney Michael M MM Elborn J Stuart JS Rodriguez-Villalobos Hector H Plésiat Patrick P Kahl Barbara C BC Denis Olivier O Winterhalter Mathias M Tulkens Paul M PM Van Bambeke Françoise F
Scientific reports 20170116
The β-lactam antibiotic temocillin (6-α-methoxy-ticarcillin) shows stability to most extended spectrum β-lactamases, but is considered inactive against Pseudomonas aeruginosa. Mutations in the MexAB-OprM efflux system, naturally occurring in cystic fibrosis (CF) isolates, have been previously shown to reverse this intrinsic resistance. In the present study, we measured temocillin activity in a large collection (n = 333) of P. aeruginosa CF isolates. 29% of the isolates had MICs ≤ 16 mg/L (propos ...[more]