Ontology highlight
ABSTRACT:
SUBMITTER: Vermote A
PROVIDER: S-EPMC5238489 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Vermote Arno A Brackman Gilles G Risseeuw Martijn D P MD Cappoen Davie D Cos Paul P Coenye Tom T Van Calenbergh Serge S
ACS medicinal chemistry letters 20161109 1
A library of 52 hamamelitannin analogues was synthesized and investigated for its ability to potentiate the effect of vancomycin toward <i>Staphylococcus aureus</i> biofilms. Several compounds were found to effectively increase the susceptibility of staphylococcal biofilms toward this glycopeptide. The most active analogue identified in this study showed an EC<sub>50</sub> value of 0.26 μM. ...[more]