Ontology highlight
ABSTRACT:
SUBMITTER: Eguaogie O
PROVIDER: S-EPMC5238552 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Eguaogie Olga O Conlon Patrick F PF Ravalico Francesco F Sweet Jamie S T JS Elder Thomas B TB Conway Louis P LP Lennon Marc E ME Hodgson David R W DR Vyle Joseph S JS
Beilstein journal of organic chemistry 20170113
Vibration ball-milling in a zirconia-lined vessel afforded clean and quantitative nucleophilic displacement reactions between 4-methoxybenzylthiolate salts and nucleoside 5'-halides or 5'-tosylates in five to 60 minutes. Under these conditions, commonly-encountered nucleoside cyclisation byproducts (especially of purine nucleosides) were not observed. Liquid-assisted grinding of the same 5'-iodide and 5'-tosylate substrates with potassium selenocyanate in the presence of DMF produced the corresp ...[more]