Ontology highlight
ABSTRACT:
SUBMITTER: Melchardt T
PROVIDER: S-EPMC5239491 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Melchardt Thomas T Hufnagl Clemens C Weinstock David M DM Kopp Nadja N Neureiter Daniel D Tränkenschuh Wolfgang W Hackl Hubert H Weiss Lukas L Rinnerthaler Gabriel G Hartmann Tanja N TN Hartmann Tanja N TN Greil Richard R Weigert Oliver O Egle Alexander A
Oncotarget 20160801 32
Little information is available about the role of certain mutations for clonal evolution and the clinical outcome during relapse in diffuse large B-cell lymphoma (DLBCL). Therefore, we analyzed formalin-fixed-paraffin-embedded tumor samples from first diagnosis, relapsed or refractory disease from 28 patients using next-generation sequencing of the exons of 104 coding genes. Non-synonymous mutations were present in 74 of the 104 genes tested. Primary tumor samples showed a median of 8 non-synony ...[more]