Ontology highlight
ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC5239552 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Zhang Fan F Wang Hongsheng H Wang Xianfeng X Jiang Guanmin G Liu Hao H Zhang Ge G Wang Hao H Fang Rui R Bu Xianzhang X Cai Shaohui S Du Jun J
Oncotarget 20160801 32
Tumor-associated macrophages (TAMs) are a major component of leukocytic infiltrate in tumors, which facilitates tumor progression and promotes inflammation. TGF-β promotes the differentiation of non-activated macrophages into a TAM-like (M2-like) phenotype; however, the underlying mechanisms are not clear. In this study, we found that TGF-β induces a M2-like phenotype characterized by up-regulation of the anti-inflammatory cytokine IL-10, and down-regulation of the pro-inflammatory cytokines TNF ...[more]