Remission of lymphoblastic leukaemia in an intravascular fluidic environment by pliable drug carrier with a sliding target ligand.
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ABSTRACT:
SUBMITTER: Jang D
PROVIDER: S-EPMC5240144 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Remission of lymphoblastic leukaemia in an intravascular fluidic environment by pliable drug carrier with a sliding target ligand.
Jang Donghyun D Lee Yeong Mi YM Lee Jaehyun J Doh Junsang J Kim Won Jong WJ
Scientific reports 20170117
A polyrotaxane-based nanoconstruct with pliable structure carrying a chemotherapeutic drug was developed for targeting circulating lymphoblastic leukaemia cells in a fluidic environment of blood vessels in vivo. By introducing lymphoblast targeting aptamer DNA through cyclodextrin, threaded in poly(ethylene glycol) as polyrotaxane, target aptamer slides along the long polymeric chain and actively search for target ligand, leading to active targeting in dynamic fluidic system which is enhanced by ...[more]
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