Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study.

ABSTRACT:

Background

Reduced renal excretion of uric acid plays a significant role in the development of hyperuricemia and gout in adults. Hyperuricemia has been associated with chronic kidney disease and cardiovascular disease in children and adults. There are limited genome-wide association studies associating genetic polymorphisms with renal urate excretion measures. Therefore, we investigated the genetic factors that influence the excretion of uric acid and related indices in 768 Hispanic children of the Viva La Familia Study.

Methods

We performed a genome-wide association analysis for 24-h urinary excretion measures such as urinary uric acid/urinary creatinine ratio, uric acid clearance, fractional excretion of uric acid, and glomerular load of uric acid in SOLAR, while accountin

SUBMITTER: Chittoor G 

PROVIDER: S-EPMC5240212 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature