Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.
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ABSTRACT:
SUBMITTER: Zhernakova A
PROVIDER: S-EPMC5240844 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.
Zhernakova Alexandra A Kurilshikov Alexander A Bonder Marc Jan MJ Tigchelaar Ettje F EF Schirmer Melanie M Vatanen Tommi T Mujagic Zlatan Z Vila Arnau Vich AV Falony Gwen G Vieira-Silva Sara S Wang Jun J Imhann Floris F Brandsma Eelke E Jankipersadsing Soesma A SA Joossens Marie M Cenit Maria Carmen MC Deelen Patrick P Swertz Morris A MA Weersma Rinse K RK Feskens Edith J M EJ Netea Mihai G MG Gevers Dirk D Jonkers Daisy D Franke Lude L Aulchenko Yurii S YS Huttenhower Curtis C Raes Jeroen J Hofker Marten H MH Xavier Ramnik J RJ Wijmenga Cisca C Fu Jingyuan J
Science (New York, N.Y.) 20160428 6285
Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition. We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA) ...[more]
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