Fecal Fat Analyses in Chronic Pancreatitis Importance of Fat Ingestion before Stool Collection.
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ABSTRACT:
SUBMITTER: Erchinger F
PROVIDER: S-EPMC5240989 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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Fecal Fat Analyses in Chronic Pancreatitis Importance of Fat Ingestion before Stool Collection.
Erchinger Friedemann F Engjom Trond T Jurmy Palwasha P Tjora Erling E Gilja Odd Helge OH Dimcevski Georg G
PloS one 20170117 1
<h4>Objective</h4>Quantitative determination of fecal fat still is the gold standard for measuring malabsorption. We evaluated the importance of standardized food intake before and under the collection of feces.<h4>Material and methods</h4>In a project, evaluating patients with suspected chronic pancreatitis (CP) and healthy volunteers (HC), stools were collected for 72 hours coupled to registration of nutritional intake over five consecutive days. Patient groups were created by a modified Layer ...[more]
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Project description:ObjectivesFecal microbiota transplantation (FMT) is a recommended therapy for recurrent Clostridioides difficile infection and is being investigated as a potential therapy for dozens of microbiota-mediated indications. Stool banks centralize FMT donor screening and FMT material preparation with the goal of expanding access to FMT material while simultaneously improving its safety, quality, and convenience. Although there are published consensuses on donor screening guidelines, there are few reports about the implementation of those guidelines in functioning stool banks.MethodsTo help inform consensus standards with data gathered from real-world settings and, in turn, to improve patient care, here we describe the general methodology used in 2018 by OpenBiome, a large stool bank, and its outputs in that year.ResultsIn 2018, the stool bank received 7,536 stool donations from 210 donors, a daily average of 20.6 donations, and processed 4,271 of those donations into FMT preparations. The median time a screened and enrolled stool donor actively donated stool was 5.8 months. The median time between the manufacture of an FMT preparation and its shipment to a hospital or physician was 8.9 months. Half of the stool bank's partner hospitals and physicians ordered an average of 0.75 or fewer FMT preparations per month.ConclusionsFurther knowledge sharing should help inform refinements of stool banking guidelines and best practices.
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